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Journal article

The continuum model of selection in human tumors: general paradigm or niche product?

Abstract:

Berger and colleagues recently proposed a continuum model of how somatic mutations cause tumors to grow, thus supplementing the established binary models, such as oncogene activation and "two hits" at tumor suppressor loci. In the basic continuum model, decreases or increases in gene function, short of full inactivation or activation, impact linearly on cancer development. An extension, called the fail-safe model, envisaged an optimum level of gene derangement for tumor growth, but proposed t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Cancer research
Volume:
72
Issue:
13
Pages:
3131-3134
Publication date:
2012-07-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
329016
Language:
English
Keywords:
Pubs id:
pubs:329016
UUID:
uuid:e6aae2c0-f45b-48e1-81ed-61eb3d26a8ec
Local pid:
pubs:329016
Deposit date:
2012-12-19

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