Journal article
The continuum model of selection in human tumors: general paradigm or niche product?
- Abstract:
-
Berger and colleagues recently proposed a continuum model of how somatic mutations cause tumors to grow, thus supplementing the established binary models, such as oncogene activation and "two hits" at tumor suppressor loci. In the basic continuum model, decreases or increases in gene function, short of full inactivation or activation, impact linearly on cancer development. An extension, called the fail-safe model, envisaged an optimum level of gene derangement for tumor growth, but proposed t...
Expand abstract
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 72
- Issue:
- 13
- Pages:
- 3131-3134
- Publication date:
- 2012-07-01
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
329016
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:329016
- UUID:
-
uuid:e6aae2c0-f45b-48e1-81ed-61eb3d26a8ec
- Local pid:
- pubs:329016
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
If you are the owner of this record, you can report an update to it here: Report update to this record