Journal article
The continuum model of selection in human tumors: general paradigm or niche product?
- Abstract:
-
Berger and colleagues recently proposed a continuum model of how somatic mutations cause tumors to grow, thus supplementing the established binary models, such as oncogene activation and "two hits" at tumor suppressor loci. In the basic continuum model, decreases or increases in gene function, short of full inactivation or activation, impact linearly on cancer development. An extension, called the fail-safe model, envisaged an optimum level of gene derangement for tumor growth, but proposed t...
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- Publication status:
- Published
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- Publisher copy:
- 10.1158/0008-5472.can-12-1052
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Bibliographic Details
- Journal:
- Cancer research
- Volume:
- 72
- Issue:
- 13
- Pages:
- 3131-3134
- Publication date:
- 2012-07-01
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Source identifiers:
-
329016
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:329016
- UUID:
-
uuid:e6aae2c0-f45b-48e1-81ed-61eb3d26a8ec
- Local pid:
- pubs:329016
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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