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Effects of control interventions on Clostridium difficile infection in England: an observational study

Abstract:

Background
The control of Clostridium difficile infections (CDI) is an international clinical challenge. Uniquely, CDI incidence in England declined by ~80% after 2006, following implementation of national control policies; we investigated their role in this decline. This study tested two hypotheses. First, if CDI declines in England were driven by changes in use of particular antibiotics, then incidence of CDI caused by resistant isolates should decline faster than that caused by suscep...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/S1473-3099(16)30514-X

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Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
Role:
Author
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Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
Role:
Author
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Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
Role:
Author
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Department:
Oxford, MSD, NIHR Oxford Biomedical Research Centre
Role:
Author
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Grant:
087646/Z/08/Z; WT098615/Z/12/Z
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Grant:
G0800778; Health Protection Research Units on Healthcare Associated Infection and Antimicrobial Resistance (grant HPRU-2012-10041) and on Modelling Methodology (grant HPRU-2012-10080)
Health Innovation Challenge Fund More from this funder
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Grant:
WT098615 and HICF-T5-358
Publisher:
Elsevier: Lancet Publisher's website
Journal:
Lancet Infectious Diseases Journal website
Volume:
17
Issue:
4
Pages:
411–421
Publication date:
2017-01-24
Acceptance date:
2016-11-14
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Pubs id:
pubs:659522
URN:
uri:e6a57699-8129-4ba0-a16a-bea0b5ef6202
UUID:
uuid:e6a57699-8129-4ba0-a16a-bea0b5ef6202
Local pid:
pubs:659522
Paper number:
4

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