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Hippocampus mediates nocebo impairment of opioid analgesia through changes in functional connectivity

Abstract:

The neural mechanisms underlying placebo analgesia have attracted considerable attention over the recent years. In contrast, little is known about the neural underpinnings of a nocebo-induced increase in pain. We previously showed that nocebo-induced hyperalgesia is accompanied by increased activity in the hippocampus that scaled with the perceived level of anxiety. As a key node of the neural circuitry of perceived threat and fear, the hippocampus has recently been proposed to coordinate def...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/ejn.15687

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-9528-3204
More by this author
Role:
Author
ORCID:
0000-0001-8899-6444
Publisher:
Wiley
Journal:
European Journal of Neuroscience More from this journal
Volume:
56
Issue:
2
Pages:
3967-3978
Publication date:
2022-06-16
Acceptance date:
2022-05-04
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Pmid:
35537867
Language:
English
Keywords:
Pubs id:
1259095
Local pid:
pubs:1259095
Deposit date:
2022-06-06

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