Investigation into the regulatory mechanism of BRCA2 stability

Thesis

Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovarian cancers. The BRCA2 protein plays a fundamental role in the repair of DNA double strand breaks by homologous recombination (HR). BRCA2 mediates the recruitment of the RAD51 recombinase to DNA damage sites, which in turn promotes homologous pairing and strand exchange during HR.

It has been reported that increased BRCA2 mRNA levels correlate with poor cancer prognosis, and recently it...

Expand abstract

Authors: Gruber, C

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: APC/C; Ubiquitin; F-box proteins; cell cycle; SCF; BRCA2; DNA damage
• Subjects: Medical Sciences; Biology (medical sciences); Biochemistry; DNA damage signalling