Journal article icon

Journal article

A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya.

Abstract:

The malarial parasite Plasmodium falciparum has acted as a potent selective force on the human genome. The particular virulence of this organism is thought to be due to the adherence of parasitised red blood cells to small vessel endothelium through several receptors, including CD36, thrombospondin and intercellular adhesion molecule 1 (ICAM-1, CD54), and parasite isolates differ in their ability to bind to each. Immunohistochemical studies have implicated ICAM-1 as of potential importance in...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/6.8.1357

Authors


Fernandez-Reyes, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Expand authors...
Journal:
Human molecular genetics
Volume:
6
Issue:
8
Pages:
1357-1360
Publication date:
1997-08-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:e66a59a1-1480-4eb7-8a5d-e8085a7bd819
Source identifiers:
15290
Local pid:
pubs:15290

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP