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Two-year follow-up study (PRIMROSE 3) to assess bone mineral density in subjects with uterine fibroids completing the PRIMROSE 1 and PRIMROSE 2 linzagolix trials

Abstract:

STUDY QUESTION: How important was the change in lumbar spine (L1–L4), femoral neck, and total hip bone mineral density (BMD) from post-treatment baseline values to 24 months after the end of treatment in PRIMROSE 1 and PRIMROSE 2 study participants? SUMMARY ANSWER: In the present study (PRIMROSE 3), mean percentage changes in lumbar spine BMD from the post-treatment baseline to month 24 (primary endpoint) were small in most treatment groups and similar to variations in the placebo group. WHAT...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hropen/hoaf025

Authors

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Role:
Author
ORCID:
0000-0003-2528-206X
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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-9870-9581


Publisher:
Oxford University Press
Journal:
Human Reproduction Open More from this journal
Volume:
2025
Issue:
3
Article number:
hoaf025
Publication date:
2025-05-13
DOI:
EISSN:
2399-3529
ISSN:
2399-3529


Language:
English
Keywords:
Pubs id:
2131797
Local pid:
pubs:2131797
Source identifiers:
3058200
Deposit date:
2025-06-27
ARK identifier:
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