Could platelet activating factor play a role in developmental dyslexia?

Journal article

Post-mortem studies by Galaburda and colleagues on the brains of developmental dyslexics found characteristic neuronal abnormalities: ectopias, microgyria, and fewer large-soma cells in sensory thalamus. An association between dyslexia and immune dysfunction has also been proposed. We describe a mechanism which may explain these observations. Platelet-activating factor (PAF) is a pro-inflammatory lipid implicated in neurological disorders. We propose that PAF may also be involved in dyslexia.

Authors: Taylor, K; Richardson, A; Stein, J

• Publication status: Published
• Journal: Prostaglandins, leukotrienes, and essential fatty acids
• Volume: 64
• Issue: 3
• Pages: 173-180
• Publication date: 2001-03-01
• DOI: 10.1054/plef.2001.0258
• EISSN: 1532-2823
• ISSN: 0952-3278
• Language: English
• Keywords: Humans; Genetic Linkage; Platelet Activating Factor; Dyslexia; Brain