Journal article
The protocol for a patient-driven on-line prospective European observational cohort aiming to determine risk factors for the development of psoriatic arthritis (PsA) amongst people living with psoriasis: the HIPPOCRATES Prospective Observational Study (HPOS)
- Alternative title:
- The HIPPOCRATES Prospective Observational Study (HPOS)
- Abstract:
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Background: Up to one-third of people living with psoriasis develop psoriatic arthritis (PsA) and the majority have active psoriasis prior to development of arthritis. Clinical risk factors, such as nail involvement, in conjunction with novel blood biomarkers could improve PsA risk monitoring and early diagnosis.
Objectives: The aim of the HIPPOCRATES Prospective Observational Study (HPOS – www.hpos.study) is to follow a cohort living with psoriasis and identify risk factors for the development of PsA.
Design: HPOS is a patient-driven on-line prospective European observational cohort.
Methods: Adult participants with psoriasis but with no prior diagnosis of PsA are eligible. Participants are invited to provide consent and join the study online. They complete a semi-structured questionnaire to collect data on demographics, psoriasis, comorbidities, risk factors for PsA and the PEST screening questionnaire. Follow-up is conducted through a questionnaire every six months. The primary outcome is the new onset of PsA confirmed by a diagnosis from their doctor. The study will also collect peripheral blood samples from a sub-set of participants for biomarker identification.
Ethics: This study follows the principles of the Declaration of Helsinki. To date, ethical approval has been granted by independent ethical committees in ten countries.
Discussion: Studying a cohort of individuals with psoriasis will allow us to identify risk factors for arthritis development and to develop a risk calculator. This can support focused efforts on screening, patient education and even studies looking to delay or prevent the onset of arthritis. This study, run via remote online data collection, provides an efficient way to recruit a large cohort (25,000) across multiple countries. However, challenges have had to be addressed with some key changes in study design, ethical review and recruitment strategies required for each individual country.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1177/1759720x251412835
Authors
- Publisher:
- SAGE Publications
- Journal:
- Therapeutic Advanced in Musculoskeletal Disease More from this journal
- Publication date:
- 2026-03-25
- Acceptance date:
- 2025-12-16
- DOI:
- EISSN:
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1759-7218
- ISSN:
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1759-720X
- Language:
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English
- Keywords:
- Pubs id:
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2352235
- Local pid:
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pubs:2352235
- Deposit date:
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2025-12-19
- ARK identifier:
Terms of use
- Copyright holder:
- Grohmann et al
- Copyright date:
- 2026
- Rights statement:
- © The Author(s), 2026. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Request permissions for this article.
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