Journal article
Acute hypercortisolemia exerts depot-specific effects on abdominal and femoral adipose tissue function.
- Abstract:
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Context
Glucocorticoids have pleiotropic metabolic functions and acute glucocorticoid excess affects fatty acid metabolism, increasing systemic lipolysis. Whether glucocorticoids exert adipose tissue depot-specific effects remains unclear.
Objective
In vivo assessment of femoral and abdominal adipose tissue responses to acute glucocorticoid administration.
Design and outcome measures
Nine healthy male volunteers studied on two occasions, following a hydrocortisone infusion (0.2 mg.kg-1.min-1 for 14 hours) and saline, respectively, given in randomized double-blind order. Subjects were studied in the fasting state and following a 75g glucose drink with in vivo assessment of femoral adipose tissue blood flow (ATBF) using radioactive Xenon washout, and lipolysis and glucose uptake using the arterio-venous difference technique. In a separate study (same infusion design), 8 further healthy male subjects underwent assessment of fasting abdominal ATBF and lipolysis only. Lipolysis was assessed as the net release of non-esterified fatty acids (NEFA) from femoral and abdominal subcutaneous adipose tissue.
Results
Acute hypercortisolemia significantly increased basal and postprandial ATBF in femoral adipose tissue, but femoral net NEFA release did not change. In abdominal adipose tissue, hypercortisolemia induced significant increases in basal ATBF and NEFA release.
Conclusions
Acute hypercortisolemia induces differential lipolysis and ATBF responses in abdominal and femoral adipose tissue, suggesting depot-specific glucocorticoid effects. Abdominal, but not femoral, adipose tissue contributes to the hypercortisolemia-induced systemic NEFA increase, with likely contributions from other adipose tissue sources and intravascular triglyceride hydrolysis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 959.0KB, Terms of use)
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- Publisher copy:
- 10.1210/jc.2016-3600
Authors
- Publisher:
- Oxford University Press
- Journal:
- Journal of Clinical Endocrinology & Metabolism More from this journal
- Volume:
- 102
- Issue:
- 4
- Pages:
- 1091-1101
- Publication date:
- 2017-02-01
- Acceptance date:
- 2017-02-13
- DOI:
- EISSN:
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1945-7197
- ISSN:
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0021-972X
- Language:
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English
- Keywords:
- Pubs id:
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pubs:687035
- UUID:
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uuid:e5fe0111-4c8e-4518-acaf-9cf2ca13f6e5
- Local pid:
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pubs:687035
- Source identifiers:
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687035
- Deposit date:
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2017-03-31
Terms of use
- Copyright holder:
- Tomlinson et al
- Copyright date:
- 2017
- Notes:
- This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
- Licence:
- CC Attribution (CC BY)
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