Increased activation of the hypoxia-inducible factor pathway in varicose veins.

Journal article

BACKGROUND: Venous hypoxia has been postulated to contribute to varicose vein (VV) formation. Direct measurements of vein wall oxygen tension have previously demonstrated that the average minimum oxygen tensions were significantly lower in VVs compared with non-varicose veins (NVVs). Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that regulate the expression of several genes of oxygen homeostasis. This study aimed to investigate if hypoxia was associated with VVs by ass...

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Authors: Lim, C; Kiriakidis, S; Paleolog, E; Davies, A

• Journal: Journal of vascular surgery
• Volume: 55
• Issue: 5
• Pages: 1427-1439
• Publication date: 2012-05-01
• DOI: 10.1016/j.jvs.2011.10.111
• EISSN: 1097-6809
• ISSN: 0741-5214
• Language: English
• Keywords: Up-Regulation; Cell Hypoxia; Proto-Oncogene Proteins; Antigens, Neoplasm; Female; Carbonic Anhydrases; Procollagen-Proline Dioxygenase; Adult; Middle Aged; Varicose Veins; Blotting, Western; Male; Reverse Transcriptase Polymerase Chain Reaction; Veins; RNA, Messenger; Time Factors; Signal Transduction; Organ Culture Techniques; Aged; Humans; Case-Control Studies; Dioxygenases; Real-Time Polymerase Chain Reaction; Basic Helix-Loop-Helix Transcription Factors; Hypoxia-Inducible Factor 1, alpha Subunit; Amino Acids, Dicarboxylic; Vascular Endothelial Growth Factor A; Aged, 80 and over; Glucose Transporter Type 1; Membrane Proteins