Journal article

Understanding and managing ischemic stroke.

Abstract:: Transient or permanent focal brain injury following acute thromboembolic occlusion develops from a complex cascade of pathophysiological events. The processes of excitotoxicity, peri-infarct depolarisation, inflammation, and apoptosis within the ischemic penumbra are proposed. While the translation of therapeutic agents from the animal models to human clinical trials have been disappointing, there remains an atmosphere of optimism as a result of the development of new diagnostic and therapeutic approaches, which include physiological, as opposed to pharmacological, intervention. This article provides an insight into the understanding of cerebral ischemia, together with current and future treatment strategies.

Publication status:: Published

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APA Style

Barber, P., Auer, R., Buchan, A., & Sutherland, G. (2001). Understanding and managing ischemic stroke. Canadian Journal of Physiology and Pharmacology, 79(3), 283–296.

MLA Style

Barber, P., et al. “Understanding and Managing Ischemic Stroke.” Canadian Journal of Physiology and Pharmacology, vol. 79, no. 3, 2001, pp. 283–96.

Chicago Style

Barber, P, R Auer, A Buchan, and G Sutherland. 2001. “Understanding and Managing Ischemic Stroke.” Canadian Journal of Physiology and Pharmacology 79 (3): 283–96.
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Publisher copy:: 10.1139/cjpp-79-3-283

Authors

+ Barber, P More by this author

Role:: Author

+ Auer, R More by this author

Role:: Author

+ Buchan, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: Stroke and Geratology
Role:: Author

+ Sutherland, G More by this author

Role:: Author

Journal:: Canadian journal of physiology and pharmacology More from this journal
Volume:: 79
Issue:: 3
Pages:: 283-296
Publication date:: 2001-03-01
DOI:: 10.1139/cjpp-79-3-283
EISSN:: 1205-7541
ISSN:: 0008-4212

Language:: English
Keywords:: Humans

Animals

Stroke

Brain Ischemia

Brain
Pubs id:: pubs:79089
UUID:: uuid:e5d894bd-df7e-4d49-9bb6-27f31499187d
Local pid:: pubs:79089
Source identifiers:: 79089
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2001

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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