Drug susceptibility of Mycobacterium tuberculosis in HIV-infected and -uninfected Ethiopians and its impact on outcome after 24 months of follow-up.

Journal article

From a prospective cohort study on tuberculosis/human immunodeficiency virus (TB/HIV) interaction in Addis Ababa, Ethiopia, drug susceptibility results were available for 94 TB patients (46% HIV-infected). Resistance to one or more drug(s) was detected in 21 (22.3%) and multidrug resistance in five (5.3%) patients. Occurrence of resistance was not related to HIV status or outcome after 24 months of follow-up. However, among HIV-infected TB patients who died during follow-up, survival time in those with a resistant Mycobacterium tuberculosis strain was significantly shorter compared to those with a sensitive strain (6 vs. 13 months). Early detection of drug resistance and timely treatment change can therefore have a positive impact on survival in HIV-infected TB patients.

Authors: Eyob, G; Guebrexabher, H; Lemma, E; Wolday, D; Gebeyehu, M

• Publication status: Published
• Journal: international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
• Volume: 8
• Issue: 11
• Pages: 1388-1391
• Publication date: 2004-11-01
• EISSN: 1815-7920
• ISSN: 1027-3719
• Language: English
• Keywords: Tuberculosis, Pulmonary; Case-Control Studies; Drug Resistance, Bacterial; Treatment Outcome; Young Adult; HIV Infections; Time Factors; Male; Mycobacterium tuberculosis; Antitubercular Agents; Prospective Studies; Ethiopia; Adult; Humans; Follow-Up Studies; Female