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Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.

Abstract:

BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha are essential regulatory proteins for the adaptation of tumor cells to hypoxia, and they stimulate angiogenesis through activation of the vascular endothelial growth factor (VEGF) gene. METHODS: HIF-1alpha and HIF-2alpha proteins were studied immunohistochemically in a group of 81 patients with Stage I endometrial adenocarcinoma of the endometrioid cell type. The results were correlated with intratumoral angiogenesis, th...

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Publication status:
Published

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Publisher copy:
10.1002/cncr.10774

Authors


Journal:
Cancer
Volume:
95
Issue:
5
Pages:
1055-1063
Publication date:
2002-09-05
DOI:
EISSN:
1097-0142
ISSN:
0008-543X
URN:
uuid:e58adde8-2cea-4a9d-86a1-a3f5837e0c7c
Source identifiers:
119344
Local pid:
pubs:119344

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