Journal article
Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma.
- Abstract:
-
BACKGROUND: Hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha are essential regulatory proteins for the adaptation of tumor cells to hypoxia, and they stimulate angiogenesis through activation of the vascular endothelial growth factor (VEGF) gene. METHODS: HIF-1alpha and HIF-2alpha proteins were studied immunohistochemically in a group of 81 patients with Stage I endometrial adenocarcinoma of the endometrioid cell type. The results were correlated with intratumoral angiogenesis, th...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/cncr.10774
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Bibliographic Details
- Journal:
- Cancer
- Volume:
- 95
- Issue:
- 5
- Pages:
- 1055-1063
- Publication date:
- 2002-09-01
- DOI:
- EISSN:
-
1097-0142
- ISSN:
-
0008-543X
- Source identifiers:
-
119344
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:119344
- UUID:
-
uuid:e58adde8-2cea-4a9d-86a1-a3f5837e0c7c
- Local pid:
- pubs:119344
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2002
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