Altered in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase in patients with manic depressive psychosis.

Journal article

When lymphocytes from healthy subjects are incubated in lithium (8 mM) or ethacrynate (1 microM) they show a time-dependent adaptive response, which consists of a significant increase in the number of Na+,K(+)-ATPase molecules in the lymphocyte membrane. We have studied the lymphocytes from nine euthymic drug-free patients with a history of manic depressive psychosis, and have found that this normal adaptive response was absent. It was also absent from the lymphocytes of euthymic patients tak...

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Authors: Wood, A; Smith, C; Clarke, E; Cowen, P; Aronson, J

• Publication status: Published
• Journal: Journal of affective disorders
• Volume: 21
• Issue: 3
• Pages: 199-206
• Publication date: 1991-03-01
• DOI: 10.1016/0165-0327(91)90040-y
• EISSN: 1573-2517
• ISSN: 0165-0327
• Language: English
• Keywords: Bipolar Disorder; Lithium Carbonate; Humans; Lymphocytes; Lithium; Psychiatric Status Rating Scales; Ouabain; Radioligand Assay; Sodium-Potassium-Exchanging ATPase