Journal article icon

Journal article

Altered in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase in patients with manic depressive psychosis.

Abstract:

When lymphocytes from healthy subjects are incubated in lithium (8 mM) or ethacrynate (1 microM) they show a time-dependent adaptive response, which consists of a significant increase in the number of Na+,K(+)-ATPase molecules in the lymphocyte membrane. We have studied the lymphocytes from nine euthymic drug-free patients with a history of manic depressive psychosis, and have found that this normal adaptive response was absent. It was also absent from the lymphocytes of euthymic patients tak...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Clarke, EE More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Expand authors...
Journal:
Journal of affective disorders
Volume:
21
Issue:
3
Pages:
199-206
Publication date:
1991-03-05
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
URN:
uuid:e56c06d6-fceb-4f45-892e-b02b9667676b
Source identifiers:
185809
Local pid:
pubs:185809

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP