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Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors.

Abstract:

Imidacloprid is increasingly used worldwide as an insecticide. It is an agonist at nicotinic acetylcholine receptors (nAChRs) and shows selective toxicity for insects over vertebrates. Recent studies using binding assays, molecular biology and electrophysiology suggest that both alpha- and non-alpha-subunits of nAChRs contribute to interactions of these receptors with imidacloprid. Electrostatic interactions of the nitroimine group and bridgehead nitrogen in imidacloprid with particular nAChR...

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Authors


Matsuda, K More by this author
Buckingham, SD More by this author
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Journal:
Trends in pharmacological sciences
Volume:
22
Issue:
11
Pages:
573-580
Publication date:
2001-11-05
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
URN:
uuid:e5614305-1d2e-4c57-b8ef-d465ec9eaf78
Source identifiers:
275976
Local pid:
pubs:275976

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