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Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice.

Abstract:

Epidemiological evidence implies a role for chronic stress and stress-related disorders in the etiopathogenesis of sporadic Alzheimer's disease (AD). Although chronic stress exposure during various stages of life has been shown to exacerbate AD-related cognitive deficits and neuropathology in AD mouse models, the role of stress exposure during the prenatal period on AD development and progression remained to be investigated. The present study therefore explored the effects of prenatal materna...

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
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Journal:
Neurobiology of aging
Volume:
34
Issue:
1
Pages:
319-337
Publication date:
2013-01-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:e54daef0-26e6-4480-b0eb-c305676c5fa5
Source identifiers:
456144
Local pid:
pubs:456144

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