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Hydroxyapatite particles are capable of inducing osteoclast formation.

Abstract:

Hydroxyapatite (HA) coatings have been used to improve implant fixation by promoting bone formation around the prosthesis. A macrophage response to HA particulates has been noted around loosened HA-coated prostheses. As biomaterial wear particle-associated macrophages are known to be capable of differentiating into osteoclasts that are capable of bone resorption, we examined whether particulate HA could similarly induce macrophage-osteoclast differentiation. HA-associated macrophages were iso...

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Publication status:
Published

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Publisher copy:
10.1023/a:1011267005465

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Journal of materials science. Materials in medicine
Volume:
12
Issue:
8
Pages:
659-664
Publication date:
2001-08-05
DOI:
EISSN:
1573-4838
ISSN:
0957-4530
URN:
uuid:e5396567-7aa1-4239-96ae-efd37e666031
Source identifiers:
62460
Local pid:
pubs:62460
Language:
English

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