Journal article
METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
- Abstract:
-
METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with METTL3 to mediate N6-methyladenosine (m6A) methylation. Recent studies identified a function for METTL3 in heterochromatin in mouse embryonic stem cells (mESCs), but the molecular function of METTL14 on chromatin in mESCs remains unclear. Here, we show that METTL14 specifically binds and regulates bivalent domains, which are marked by trimethylation of histone H3 lysine 27 (H3K27me3) and lys...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 5.4MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.celrep.2023.112650
Authors
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Cell Reports More from this journal
- Volume:
- 42
- Issue:
- 6
- Article number:
- 112650
- Place of publication:
- United States
- Publication date:
- 2023-06-13
- Acceptance date:
- 2023-05-30
- DOI:
- ISSN:
-
2211-1247
- Pmid:
-
37314930
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
-
1408821
- Local pid:
-
pubs:1408821
- Deposit date:
-
2023-07-11
Terms of use
- Copyright holder:
- Mu et al.
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Author(s). This is an open access article under the CC BY-NC-ND license.
- Notes:
- A correction to this article is available online from Cell Press at: https://doi.org/10.1016/j.celrep.2023.113116.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record