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Preexisting influenza-specific CD4 + T cells correlate with disease protection against influenza challenge in humans

Abstract:

Protective immunity against influenza virus infection is mediated by neutralizing antibodies, but the precise role of T cells in human influenza immunity is uncertain. We conducted influenza infection studies in healthy volunteers with no detectable antibodies to the challenge viruses H3N2 or H1N1. We mapped T cell responses to influenza before and during infection. We found a large increase in influenza-specific T cell responses by day 7, when virus was completely cleared from nasal samples ...

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Publisher copy:
10.1038/nm.2612

Authors


Wilkinson, TM More by this author
Huang, AKY More by this author
Huang, AKY More by this author
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Journal:
Nature Medicine
Volume:
18
Issue:
2
Pages:
274-280
Publication date:
2012-02-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:e4e8f243-61a1-4e00-ad18-6f9de3e8e35f
Source identifiers:
341456
Local pid:
pubs:341456

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