Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.

Journal article

Genetic studies in human populations and rodent models have identified regions of human chromosome 1q21-25 and rat chromosome 2 showing evidence of significant and replicated linkage to diabetes-related phenotypes. To investigate the relationship between the human and rat diabetes loci, we fine mapped the rat locus Nidd/gk2 linked to hyperinsulinemia in an F2 cross derived from the diabetic (type 2) Goto-Kakizaki (GK) rat and the Brown Norway (BN) control rat, and carried out its genetic and ...

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Authors: Wallace, K; Wallis, R; Collins, S; Argoud, K; Kaisaki, P

• Publication status: Published
• Journal: Physiological genomics
• Volume: 19
• Issue: 1
• Pages: 1-10
• Publication date: 2004-09-01
• DOI: 10.1152/physiolgenomics.00114.2004
• EISSN: 1531-2267
• ISSN: 1094-8341
• Language: English
• Keywords: Humans; Genomics; Phenotype; Animals; Transcription, Genetic; Crosses, Genetic; Chromosomes, Human, Pair 1; Animals, Congenic; Sequence Analysis, DNA; Lipids; Quantitative Trait Loci; Rats, Inbred BN; Conserved Sequence; Insulin; Rats, Inbred Strains; Glucose; Glucose Intolerance; Female; Rats; Polymorphism, Genetic; Male; Diabetes Mellitus, Type 2; Gene Expression Profiling; Body Weight; Hyperinsulinism