Journal article icon

Journal article

Variants of the CD40 ligand gene are not associated with increased susceptibility to tuberculosis in West Africa.

Abstract:

Evidence for linkage between tuberculosis and human chromosomal region Xq26 has previously been described. The costimulatory molecule CD40 ligand, encoded by TNFSF5 and located at Xq26.3, is a promising positional candidate. Interactions between CD40 ligand and CD40 are involved in the development of humoral- and cell-mediated immunity, as well as the activation of macrophages, which are the primary host and effector cells for Mycobacterium tuberculosis. We hypothesised that common variation ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00251-003-0602-9

Authors


Campbell, SJ More by this author
Fielding, K More by this author
Expand authors...
Journal:
Immunogenetics
Volume:
55
Issue:
7
Pages:
502-507
Publication date:
2003-10-05
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:e4c560c7-c893-429c-afef-559f1987effc
Source identifiers:
32449
Local pid:
pubs:32449

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP