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Sensitization to the lysosomal cell death pathway upon immortalization and transformation.

Abstract:

Tumorigenesis is associated with several changes that alter the cellular susceptibility to programmed cell death. Here, we show that immortalization and transformation sensitize cells in particular to the cysteine cathepsin-mediated lysosomal death pathway. Spontaneous immortalization increased the susceptibility of wild-type murine embryonic fibroblasts (MEFs) to tumor necrosis factor (TNF)-mediated cytotoxicity >1000-fold, whereas immortalized MEFs deficient for lysosomal cysteine protea...

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Authors


Fehrenbacher, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Poulsen, B More by this author
Kallunki, T More by this author
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Journal:
Cancer research
Volume:
64
Issue:
15
Pages:
5301-5310
Publication date:
2004-08-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:e4c3cec3-bdef-4573-8b87-fc612d3ccb86
Source identifiers:
429225
Local pid:
pubs:429225

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