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Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases.

Abstract:

Campath-1 (CDw52) antibodies (IgM and IgG2b) have been used in vitro and in vivo for control of GVHD and prevention of rejection following bone marrow transplantation. Results of 951 patients with malignant disease transplanted from HLA-matched siblings are reported. Both Campath-1M and Campath-1G are shown to be effective when used in vitro for prevention of graft-versus-host disease (GVHD). Graft failure was reduced by addition of cyclosporin A (CsA) post-transplant and possibly also by tot...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Bone marrow transplantation
Volume:
13
Issue:
5
Pages:
597-611
Publication date:
1994-05-05
EISSN:
1476-5365
ISSN:
0268-3369
URN:
uuid:e4bef1c5-9686-469f-a88a-76361d6b9870
Source identifiers:
29598
Local pid:
pubs:29598

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