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Journal article

Structural basis for the interference between nicorandil and sulfonylurea action.

Abstract:

Nicorandil is a new antianginal agent that potentially may be used to treat the cardiovascular side effects of diabetes. It is both a nitric oxide donor and an opener of ATP-sensitive K(+) (K(ATP)) channels in muscle and thereby causes vasodilation of the coronary vasculature. The aim of this study was to investigate the domains of the K(ATP) channel involved in nicorandil activity and to determine whether nicorandil interacts with hypoglycemic sulfonylureas that target K(ATP) channels in pan...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.50.10.2253

Authors


Reimann, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Gribble, FM More by this author
Journal:
Diabetes
Volume:
50
Issue:
10
Pages:
2253-2259
Publication date:
2001-10-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:e4871482-6af4-4107-81e6-e6c79cba38ea
Source identifiers:
114559
Local pid:
pubs:114559

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