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Journal article

Identification of radiation-responsive genes in vitro using a gene trap strategy predicts for modulation of expression by radiation in vivo.

Abstract:

A large number of genes are known to be responsive to ionizing radiation, and there is strong evidence for the existence of inducible radiation resistance in mammalian cells. We have developed a gene trap insertional mutagenesis strategy to identify novel genes involved in responses to radiation. Using this approach, we have isolated four gene-trap integrations in embryonic stem cells. In three cases (9A, 3E and 9H) the trapped genes are radiation-inducible, and in one (7D) the gene is down-r...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Journal:
Radiation research
Volume:
157
Issue:
1
Pages:
8-18
Publication date:
2002-01-05
DOI:
EISSN:
1938-5404
ISSN:
0033-7587
URN:
uuid:e4819a4e-f181-4d2e-8d20-bab6b83ea15f
Source identifiers:
131169
Local pid:
pubs:131169

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