Aortic thrombosis in COVID-19

Journal article

Background Venous thrombo-embolism is now well-recognised as a common complication of severe COVID-19 disease. Arterial thrombosis has been less well recognised, although it is increasingly reported, mostly in the context of myocardial infarction and stroke. Case report A 63-year-old man developed a pale, cold foot with an absent dorsalis pedis pulse 7 days into his admission with COVID-19. A CT angiogram demonstrated a large thrombus in the lower thoracic aorta, which had not been present on CT pulmonary angiogram the preceding week, along with occlusion of both popliteal arteries. He was managed with therapeutic dose of low molecular weight heparin (LMWH) for 6 weeks. Results This case adds to the growing list of potential sites and consequences of thrombosis in COVID-19. Conclusion This case underscores the urgent need for pathophysiological studies and clinical trials to target treatments and guidelines for thromboprophylaxis in COVID-19.

Authors: Wickham, H; Tam, JCH; Chan, XHS; George, MJ; Levi, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Clinical Infection in Practice
• Volume: 9
• Article number: 100059
• Publication date: 2020-12-07
• Acceptance date: 2020-11-24
• DOI: 10.1016/j.clinpr.2020.100059
• ISSN: 2590-1702
• Language: English
• Keywords: FFR