Simulation studies of the interaction of antimicrobial peptides and lipid bilayers.

Journal article

Experimental studies of a number of antimicrobial peptides are sufficiently detailed to allow computer simulations to make a significant contribution to understanding their mechanisms of action at an atomic level. In this review we focus on simulation studies of alamethicin, melittin, dermaseptin and related antimicrobial, membrane-active peptides. All of these peptides form amphipathic alpha-helices. Simulations allow us to explore the interactions of such peptides with lipid bilayers, and t...

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Authors: La Rocca, P; Biggin, P; Tieleman, D; Sansom, MS

• Publication status: Published
• Journal: Biochimica et biophysica acta
• Volume: 1462
• Issue: 1-2
• Pages: 185-200
• Publication date: 1999-12-01
• DOI: 10.1016/s0005-2736(99)00206-0
• ISSN: 0006-3002
• Language: English
• Keywords: Antimicrobial Cationic Peptides; Anti-Infective Agents; Molecular Sequence Data; Models, Molecular; Melitten; Lipid Bilayers; Computer Simulation; Solvents; Alamethicin; Amphibian Proteins; Permeability; Thermodynamics; Peptides; Amino Acid Sequence; Phospholipids