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Stochasticity in Action Potential duration Enhances Dispersion of Repolarisation at Fast Pacing Rates

Abstract:

Patch clamp recordings of isolated ventricular myocytes frequently display a temporal variability in the action potential duration. Intercellular coupling through gap junctions has been shown to reduce such variability which may return as coupling is reduced. A phenomenological model capable of accurately capturing action potential morphology and variability observed in experimental data has been developed with tunable restitution properties. The phenomenological formulation also allows fast ...

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Publisher copy:
10.1016/j.bpj.2011.11.3230

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Volume:
102
Publication date:
2012-01-01
DOI:
URN:
uuid:e415cfb5-a84f-42e4-95fa-d8dba8c6ef41
Local pid:
cs:5927

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