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Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

Abstract:

CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of patients who have acute myeloid leukemia (AML). We previously showed that mutations which dissociate the ability of C/EBP alpha to block cell cycle progression through E2F inhibition from its function as a transcriptional activator impair the in vivo development of the neutrophil granulocyte and ...

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Publisher copy:
10.1084/jem.20050067

Authors


Theilgaard-Mönch, K More by this author
Hasemann, MS More by this author
Anderson, K More by this author
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Journal:
The Journal of experimental medicine
Volume:
202
Issue:
1
Pages:
85-96
Publication date:
2005-07-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:e40d5485-0770-414a-9451-249d4940bc73
Source identifiers:
324047
Local pid:
pubs:324047

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