Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage.

Journal article

CCAAT/enhancer binding protein (C/EBP)alpha is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of patients who have acute myeloid leukemia (AML). We previously showed that mutations which dissociate the ability of C/EBP alpha to block cell cycle progression through E2F inhibition from its function as a transcriptional activator impair the in vivo development of the neutrophil granulocyte and ...

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Authors: Porse, B; Bryder, D; Theilgaard-Mönch, K; Hasemann, MS; Anderson, K

• Journal: Journal of experimental medicine
• Volume: 202
• Issue: 1
• Pages: 85-96
• Publication date: 2005-07-01
• DOI: 10.1084/jem.20050067
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Leukemia, Myeloid, Acute; Mutation; Cell Transformation, Neoplastic; Mice, Inbred C57BL; Cell Proliferation; Animals; Bone Marrow Transplantation; Granulocytes; Myeloid Progenitor Cells; Phenotype; Mice; Humans; Mice, Mutant Strains; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Neutrophils; Cell Cycle; Myeloproliferative Disorders