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Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.

Abstract:

Selection by host immunity and antimalarial drugs has driven extensive adaptive evolution in Plasmodium falciparum and continues to produce ever-changing landscapes of genetic variation.We performed whole-genome sequencing of 69 P. falciparum isolates from Malawi and used population genetics approaches to investigate genetic diversity and population structure and identify loci under selection.High genetic diversity (π = 2.4 × 10(-4)), moderately high multiplicity of infection (2.7), and low l...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jiu349

Authors


Ocholla, H More by this author
Preston, MD More by this author
Mipando, M More by this author
Jensen, AT More by this author
Campino, S More by this author
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Journal:
The Journal of infectious diseases
Volume:
210
Issue:
12
Pages:
1991-2000
Publication date:
2014-12-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:e3f60d4e-33bc-4654-b1e8-b851930d0e82
Source identifiers:
471109
Local pid:
pubs:471109

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