Whole-genome scans provide evidence of adaptive evolution in Malawian Plasmodium falciparum isolates.
Selection by host immunity and antimalarial drugs has driven extensive adaptive evolution in Plasmodium falciparum and continues to produce ever-changing landscapes of genetic variation.We performed whole-genome sequencing of 69 P. falciparum isolates from Malawi and used population genetics approaches to investigate genetic diversity and population structure and identify loci under selection.High genetic diversity (π = 2.4 × 10(-4)), moderately high multiplicity of infection (2.7), and low l...Expand abstract
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