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Oxidative stress in endometriosis induces IL-8 release directly via 4-HNE

Abstract:
Lipid peroxidation products, e.g. 4-hydroxynonenal (4-HNE), are generated by oxidative stress, and are suggested to cause endometriosis-associated pain following iron overload after retrograde menstrual bleeding. Our aim was to determine the role of oxidative stress including 4-HNE protein adduct formation in endometriotic lesions and in peritoneal fluid from endometriosis patients; and characterise the proinflammatory effects caused by 4-HNE in endometriosis.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1177/1933719118759999

Authors

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women's and Reproductive Health
Role:
Author


Publisher:
SAGE Publications
Host title:
65th Annual Scientific Meeting of the Society for Reproductive Investigation
Journal:
65th Annual Scientific Meeting of the Society for Reproductive Investigation More from this journal
Publication date:
2018-02-28
Acceptance date:
2017-02-28
DOI:
EISSN:
1933-7205
ISSN:
1933-7191


Pubs id:
pubs:844518
UUID:
uuid:e3ee8f83-1d58-4741-bd6e-c91d9a5d55cb
Local pid:
pubs:844518
Source identifiers:
844518
Deposit date:
2018-05-02
ARK identifier:

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