Dynamic nucleosomes and gene transcription.

Journal article

Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.

Authors: Mellor, J

• Publication status: Published
• Journal: Trends in genetics : TIG
• Volume: 22
• Issue: 6
• Pages: 320-329
• Publication date: 2006-06-01
• DOI: 10.1016/j.tig.2006.03.008
• ISSN: 0168-9525
• Language: English
• Keywords: Humans; Chromatin; Amino Acid Sequence; Acetylation; Transcription, Genetic; Dimerization; Histones; Methylation; Nucleosomes; Histone Deacetylases; Molecular Sequence Data; Animals