Journal article icon

Journal article

Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal

Abstract:

Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural abnormality generates simultaneous 3p loss and 5q gain (36% patients), typically th...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cell.2018.02.020

Authors


More by this author
Role:
Author
ORCID:
0000-0003-0761-9503
Expand authors...
More from this funder
Grant:
project PREDICT ID number 259303
Cancer Research UK More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Volume:
173
Issue:
3
Pages:
611-623.e17
Publication date:
2018-04-12
Acceptance date:
2018-02-07
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pmid:
29656891
Source identifiers:
834749
Language:
English
Keywords:
Pubs id:
pubs:834749
UUID:
uuid:e3aa26d0-f8e6-4b68-8d7d-5aba7f03212a
Local pid:
pubs:834749
Deposit date:
2018-04-28

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP