Journal article
Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal
- Abstract:
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Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural abnormality generates simultaneous 3p loss and 5q gain (36% patients), typically th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 7.2MB)
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- Publisher copy:
- 10.1016/j.cell.2018.02.020
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Authors
Funding
Cancer Research UK
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 173
- Issue:
- 3
- Pages:
- 611-623.e17
- Publication date:
- 2018-04-12
- Acceptance date:
- 2018-02-07
- DOI:
- EISSN:
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1097-4172
- ISSN:
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0092-8674
- Pmid:
-
29656891
- Source identifiers:
-
834749
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:834749
- UUID:
-
uuid:e3aa26d0-f8e6-4b68-8d7d-5aba7f03212a
- Local pid:
- pubs:834749
- Deposit date:
- 2018-04-28
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2018
- Notes:
- Crown Copyright ©2018 Published by Elsevier Inc. This is an open access article under the CC BY license.
- Licence:
- CC Attribution (CC BY)
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