- Abstract:
-
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural abnormality generates simultaneous 3p loss and 5q gain (36% patients), typically th...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 7.2MB)
-
- Publisher copy:
- 10.1016/j.cell.2018.02.020
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Journal website
- Issue:
- 3
- Publication date:
- 2018-04-12
- Acceptance date:
- 2018-02-07
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Pubs id:
-
pubs:834749
- URN:
-
uri:e3aa26d0-f8e6-4b68-8d7d-5aba7f03212a
- UUID:
-
uuid:e3aa26d0-f8e6-4b68-8d7d-5aba7f03212a
- Local pid:
- pubs:834749
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2018
- Notes:
- Crown Copyright ©2018 Published by Elsevier Inc. This is an open access article under the CC BY license.
Journal article
Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Wellcome Trust
More from this funder
Cancer Research UK
More from this funder
Bibliographic Details
Item Description
Terms of use
If you are the owner of this record, you can report an update to it here: Report update to this record