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Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal

Abstract:

Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural abnormality generates simultaneous 3p loss and 5q gain (36% patients), typically th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cell.2018.02.020

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Role:
Author
ORCID:
0000-0003-0761-9503
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Grant:
project PREDICT ID number 259303
Wellcome Trust More from this funder
Cancer Research UK More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Journal website
Issue:
3
Publication date:
2018-04-12
Acceptance date:
2018-02-07
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pubs id:
pubs:834749
URN:
uri:e3aa26d0-f8e6-4b68-8d7d-5aba7f03212a
UUID:
uuid:e3aa26d0-f8e6-4b68-8d7d-5aba7f03212a
Local pid:
pubs:834749
Language:
English
Keywords:

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