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Production of PGE2 by bovine cultured airway smooth muscle cells and its inhibition by cyclo-oxygenase inhibitors.

Abstract:

1. Prostaglandin E2 (PGE2) is thought to be an important inhibitory modulator of inflammatory processes in the airway. It inhibits inflammatory cell function and cholinergic neurotransmission in vitro and roles have been postulated in vivo in refractoriness and in the mechanism of action of the diuretic agent, frusemide. 2. The production of PGE2 by bovine cultured airway smooth muscle cells has been studied under a range of conditions. The effects of cyclo-oxygenase inhibitors (flurbiprofen,...

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Authors


Delamere, F More by this author
Holland, E More by this author
Bennett, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
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Journal:
British journal of pharmacology
Volume:
111
Issue:
4
Pages:
983-988
Publication date:
1994-04-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:e39e8bdf-0e31-4809-8ff4-ca8eb1baba39
Source identifiers:
435409
Local pid:
pubs:435409

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