- Abstract:
-
Mutations in the leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease, chronic inflammation and mycobacterial infections. Although there is evidence supporting the idea that LRRK2 has an immune function, the cellular function of this kinase is still largely unknown. By using genetic, pharmacological and proteomics approaches, we show that LRRK2 kinase activity negatively regulates phagosome maturation via the recruitment of the Class III phosphatidylinositol-3 kinase c...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.6MB)
-
- Publisher copy:
- 10.15252/embj.201798694
-
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- Publisher:
- EMBO Press Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 37
- Issue:
- 12
- Pages:
- e98694
- Publication date:
- 2018-05-22
- Acceptance date:
- 2018-04-24
- DOI:
- ISSN:
-
1460-2075 and 0261-4189
- Pubs id:
-
pubs:854458
- URN:
-
uri:e39893bf-ba57-44fe-9b1e-c8457c7e52ab
- UUID:
-
uuid:e39893bf-ba57-44fe-9b1e-c8457c7e52ab
- Local pid:
- pubs:854458
- Language:
- English
- Keywords:
- Copyright holder:
- © 2018 The Francis Crick Institute.
- Copyright date:
- 2018
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
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