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Journal article

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Abstract:

Mutations in the leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease, chronic inflammation and mycobacterial infections. Although there is evidence supporting the idea that LRRK2 has an immune function, the cellular function of this kinase is still largely unknown. By using genetic, pharmacological and proteomics approaches, we show that LRRK2 kinase activity negatively regulates phagosome maturation via the recruitment of the Class III phosphatidylinositol-3 kinase c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.15252/embj.201798694

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Funding agency for:
Cowley, SA
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Funding agency for:
Cowley, SA
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Funding agency for:
Cowley, SA
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
37
Issue:
12
Pages:
e98694
Publication date:
2018-05-22
Acceptance date:
2018-04-24
DOI:
ISSN:
1460-2075 and 0261-4189
Pubs id:
pubs:854458
URN:
uri:e39893bf-ba57-44fe-9b1e-c8457c7e52ab
UUID:
uuid:e39893bf-ba57-44fe-9b1e-c8457c7e52ab
Local pid:
pubs:854458

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