Journal article icon

Journal article

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Abstract:

Mutations in the leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease, chronic inflammation and mycobacterial infections. Although there is evidence supporting the idea that LRRK2 has an immune function, the cellular function of this kinase is still largely unknown. By using genetic, pharmacological and proteomics approaches, we show that LRRK2 kinase activity negatively regulates phagosome maturation via the recruitment of the Class III phosphatidylinositol-3 kinase c...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.15252/embj.201798694

Authors


Expand authors...
More from this funder
Funding agency for:
Cowley, SA
Grant:
LC0910‐004
More from this funder
Funding agency for:
Cowley, SA
Grant:
LC0910‐004
More from this funder
Funding agency for:
Cowley, SA
Grant:
LC0910‐004
More from this funder
Funding agency for:
Cowley, SA
Grant:
LC0910‐004
More from this funder
Funding agency for:
Lewis, PA
Grant:
F1002
Expand funders...
Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
37
Issue:
12
Pages:
e98694
Publication date:
2018-05-22
Acceptance date:
2018-04-24
DOI:
ISSN:
0261-4189 and 1460-2075
Pmid:
29789389
Source identifiers:
854458
Language:
English
Keywords:
Pubs id:
pubs:854458
UUID:
uuid:e39893bf-ba57-44fe-9b1e-c8457c7e52ab
Local pid:
pubs:854458
Deposit date:
2018-08-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP