Journal article
IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity
- Abstract:
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BACKGROUND: IMI2-PainCare-BioPain-RCT2 is one of four similarly designed clinical studies aiming at profiling a set of functional biomarkers of drug effects on specific compartments of the nociceptive system that could serve to accelerate the future development of analgesics. IMI2-PainCare-BioPain-RCT2 will focus on human spinal cord and brainstem activity using biomarkers derived from non-invasive neurophysiological measurements. METHODS: This is a multisite, single-dose, double-blind, rando...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1186/s13063-022-06431-5
Authors
+ Innovative Medicines Initiative
More from this funder
- Funder identifier:
- https://ror.org/019af4n30
- Grant:
- 777500
- Publisher:
- BioMed Central
- Journal:
- Trials More from this journal
- Volume:
- 23
- Issue:
- 1
- Pages:
- 739
- Publication date:
- 2022-09-05
- DOI:
- EISSN:
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1745-6215
- ISSN:
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1745-6215
- Language:
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English
- Keywords:
- Pubs id:
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1278025
- Local pid:
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pubs:1278025
- Source identifiers:
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W4294578987
- Deposit date:
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2025-10-02
- ARK identifier:
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- Copyright date:
- 2022
- Licence:
- CC Attribution (CC BY)
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