Journal article icon

Journal article

An Ad/MVA vectored Theileria parva antigen induces schizont-specific CD8+ central memory T cells and confers partial protection against a lethal challenge

Abstract:

The parasite Theileria parva is the causative agent of East Coast fever (ECF), one of the most serious cattle diseases in sub-Saharan Africa, and directly impacts smallholder farmers' livelihoods. There is an efficient live-parasite vaccine, but issues with transmission of vaccine strains, need of a cold chain, and antibiotics limit its utilization. This has fostered research towards subunit vaccination. Cytotoxic T lymphocytes (CTL) are crucial in combating the infection by lysing T. parva-i...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41541-018-0073-5

Authors


More by this author
ORCID:
0000-0002-4539-5806
Muriuki, R More by this author
Expand authors...
Department for International Development More from this funder
United States Agency for International Development More from this funder
United States Department of Agriculture More from this funder
CGIAR Research Program on Livestock and Fish More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
NPJ Vaccines Journal website
Volume:
3
Issue:
1
Pages:
35
Publication date:
2018-09-11
Acceptance date:
2018-07-02
DOI:
EISSN:
2059-0105
ISSN:
2059-0105
Pubs id:
pubs:922449
URN:
uri:e366ce29-2907-40e0-a6d4-28e26d4c8af7
UUID:
uuid:e366ce29-2907-40e0-a6d4-28e26d4c8af7
Local pid:
pubs:922449
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP