Journal article
Folic acid for the prevention of neural tube defects.
- Abstract:
- The editorial by Mitchell welcomed the USPSTF recommendation that women of child-bearing age in USA should take a daily supplement containing 400-800 μg of folic acid to prevent neural tube defects (NTDs). But the rationale for the recommendation is puzzling. The recommendation makes sense for countries without mandatory folic acid fortification. However, as Mitchell says, two case-control studies in the USA after fortification have failed to show an additional benefit of folic acid supplementation in the prevention of NTDs. Mitchell suggests that folic acid fortification may be preventing nearly all cases of folic acid–related NTDs. Her suggestion is consistent with a ‘floor-effect’ for folate-sensitive NTDs
- Publication status:
- Published
- Peer review status:
- Reviewed (other)
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 173.2KB, Terms of use)
-
- Publisher copy:
- 10.1001/jamapediatrics.2017.0866
Authors
- Publisher:
- American Medical Association
- Journal:
- JAMA Pediatrics More from this journal
- Volume:
- 171
- Issue:
- 7
- Pages:
- 710-711
- Publication date:
- 2017-05-30
- Acceptance date:
- 2017-04-26
- DOI:
- EISSN:
-
2168-6211
- ISSN:
-
2168-6203
- Pmid:
-
28558107
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:698124
- UUID:
-
uuid:e3548e82-5404-4bd7-a045-8d9e3e82b102
- Local pid:
-
pubs:698124
- Source identifiers:
-
698124
- Deposit date:
-
2018-02-20
Terms of use
- Copyright holder:
- American Medical Association
- Copyright date:
- 2017
- Notes:
- © 2017 American Medical Association. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from the American Medical Association at: http://dx.doi.org/10.1001/jamapediatrics.2017.0866
If you are the owner of this record, you can report an update to it here: Report update to this record