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Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

Abstract:

Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet, when WASP function is eliminated there is negligible effect on actin polymerization at the immunological synapse, leading to gaps in our understanding of the events connecting WASP and calcium ion signaling. Here, we identify a fraction of t...

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Publication status:
Published
Peer review status:
Peer reviewed

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10.7554/eLife.04953#sthash.IAL4cyu3.dpuf

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Department:
Kennedy Institute of Rheumatology
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Department:
Kennedy Institute of Rheumatology
Darrell J Irvine More by this author
Sudha Kumari More by this author
Roberta Martinelli More by this author
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Grant:
R37AI043542
Funding agency for:
David Depoil
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Grant:
PN2EY016586
Funding agency for:
David Depoil
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Grant:
Annual Grant
Funding agency for:
David Depoil
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Grant:
NYUMC microscopy core
Funding agency for:
David Depoil
Publisher:
eLife Sciences Publisher's website
Journal:
eLIFE
Volume:
2015;4:e04953
DOI:
ISSN:
2050-084X
Language:
English
Keywords:
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