Genes in the spondyloarthropathies.

Journal article

Ankylosing spondylitis is a highly genetic disease, with up to 98% of the population variance genetically determined. The major genetic effect arises from HLA-B27, but other HLA class I molecules, including HLA-B60, also play a role. HLA class II association may indicate either an independent effect for these genes or the existence of extended MHC haplotype containing other relevant genetic loci. The HLA-linked component of the genetic contribution to AS is substantially less than 50%, and preliminary analysis of affected sibling pairs by whole genome screening has revealed several potential regions of interest. The next 5 years should lead to the confirmation of some of these linkages, their refinement, and the testing of candidate genes within them. Ultimately, a better understanding of the genetic etiology of AS should yield insight into the pathogenic mechanisms and the development of novel strategies for treatment and prevention.

Authors: Wordsworth, P

• Publication status: Published
• Journal: Rheumatic diseases clinics of North America
• Volume: 24
• Issue: 4
• Pages: 845-863
• Publication date: 1998-11-01
• DOI: 10.1016/S0889-857X(05)70045-4
• EISSN: 1558-3163
• ISSN: 0889-857X
• Language: English
• Keywords: HLA-B27 Antigen; Genetic Screening; Humans; Spondylitis, Ankylosing