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Evolutionarily conserved protein sequences of influenza a viruses, avian and human, as vaccine targets.

Abstract:

BACKGROUND: Influenza A viruses generate an extreme genetic diversity through point mutation and gene segment exchange, resulting in many new strains that emerge from the animal reservoirs, among which was the recent highly pathogenic H5N1 virus. This genetic diversity also endows these viruses with a dynamic adaptability to their habitats, one result being the rapid selection of genomic variants that resist the immune responses of infected hosts. With the possibility of an influenza A pande...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0001190

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Srinivasan, KN More by this author
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National Institute of Allergy and Infectious Diseases More from this funder
National Institutes of Health More from this funder
Department of Health and Human Services More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
2
Issue:
11
Pages:
Article: e1190
Publication date:
2007
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:e30e86d5-8634-498b-bcdf-be5df2ef7b5b
Source identifiers:
34054
Local pid:
pubs:34054

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