Journal article icon

Journal article

A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses.

Abstract:

To generate broadly protective T cell responses more similar to those acquired after vaccination with radiation-attenuated Plasmodium falciparum sporozoites, we have constructed candidate subunit malaria vaccines expressing six preerythrocytic antigens linked together to produce a 3240-aa-long polyprotein (L3SEPTL). This polyprotein was expressed by a plasmid DNA vaccine vector (DNA) and by two attenuated poxvirus vectors, modified vaccinia virus Ankara (MVA) and fowlpox virus of the FP9 stra...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.0307158101

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Schneider, J More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
1
Pages:
290-295
Publication date:
2004-01-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e2e7b99d-4915-4b3c-b3f5-0b50abe31dee
Source identifiers:
32583
Local pid:
pubs:32583

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP