- Abstract:
-
To generate broadly protective T cell responses more similar to those acquired after vaccination with radiation-attenuated Plasmodium falciparum sporozoites, we have constructed candidate subunit malaria vaccines expressing six preerythrocytic antigens linked together to produce a 3240-aa-long polyprotein (L3SEPTL). This polyprotein was expressed by a plasmid DNA vaccine vector (DNA) and by two attenuated poxvirus vectors, modified vaccinia virus Ankara (MVA) and fowlpox virus of the FP9 stra...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0307158101
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 101
- Issue:
- 1
- Pages:
- 290-295
- Publication date:
- 2004-01-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:e2e7b99d-4915-4b3c-b3f5-0b50abe31dee
- Source identifiers:
-
32583
- Local pid:
- pubs:32583
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses.
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