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Thesis

Regulation of the deubiquitinase CYLD in innate immune signalling

Abstract:

Innate immune receptors are vital for protection against invading pathogens and the downstream signalling events of these are controlled by ubiquitination. Classically, ubiquitin was described to serve as a degradative signal. However, of the eight possible types of ubiquitin linkages, most have been assigned non-degradative roles and instead serve scaffolding functions for recruitment and activation of proteins. M1- and K63- chains are two such linkages and have crucial roles in medi...

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Department:
University of Oxford
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Author

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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