Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation.

Journal article

Efficient T cell activation requires the engagement of a variety of ligand/receptor molecules in addition to T cell receptor (TCR)-major histocompatibility complex (MHC)/peptide interactions. The leukocyte function antigen 1 (LFA-1) and the CD28 glycoprotein have both been implicated in T cell activation. The present study dissects the roles of LFA-1 and CD28 in the activation of naive virus-specific CD8+ T cells. We demonstrate that LFA-1 facilitates T cell activation by lowering the amounts...

Expand abstract

Authors: Bachmann, M; McKall-Faienza, K; Schmits, R; Bouchard, D; Beach, J

• Publication status: Published
• Journal: Immunity
• Volume: 7
• Issue: 4
• Pages: 549-557
• Publication date: 1997-10-01
• DOI: 10.1016/s1074-7613(00)80376-3
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Antigens, Viral; Down-Regulation; Peptides; Antigens, CD28; Mice, Transgenic; Lymphocytic choriomeningitis virus; Interleukin-2; Cell Adhesion Molecules; Lymphocyte Activation; Signal Transduction; Lymphocyte Function-Associated Antigen-1; Receptors, Antigen, T-Cell; Clonal Anergy; Animals; Cell Adhesion; Calcium; Antigen-Presenting Cells; Mice; T-Lymphocytes