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The impact of immunoglobulin in acute HIV infection on the HIV reservoir: a randomized controlled trial

Abstract:

Objectives

Antiretroviral therapy (ART) during acute HIV infection (AHI) restricts the HIV reservoir, but additional interventions are necessary to induce a cure. Intravenous immunoglobulin (IVIG) is not HIV-specific but is safe and temporarily reduces the HIV reservoir in chronic HIV infection. We present a randomized controlled trial to investigate whether IVIG plus ART in AHI reduces the HIV reservoir and immune activation compared with ART alone.

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Ten m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/hiv.12524

Authors


Tiraboschi, J More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
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Guy's Charity More from this funder
Publisher:
Wiley Publisher's website
Journal:
HIV Medicine Journal website
Volume:
18
Issue:
10
Pages:
777-781
Publication date:
2017-07-05
Acceptance date:
2017-04-12
DOI:
EISSN:
1468-1293
ISSN:
1464-2662
Pubs id:
pubs:811735
URN:
uri:e2850758-00e6-4576-8f9f-d376cf80ca5f
UUID:
uuid:e2850758-00e6-4576-8f9f-d376cf80ca5f
Local pid:
pubs:811735

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