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Infrared Laser Activation of Soluble and Membrane Protein Assemblies in the Gas Phase

Abstract:

Collision-induced dissociation (CID) is the dominant method for probing intact macromolecular complexes in the gas phase by means of mass spectrometry (MS). The energy obtained from collisional activation is dependent on the charge state of the ion and the pressures and potentials within the instrument: these factors limit CID capability. Activation by infrared (IR) laser radiation offers an attractive alternative as the radiation energy absorbed by the ions is charge-state-independent and th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1021/acs.analchem.6b00645

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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
More by this author
Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
More by this author
Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
More by this author
Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
More by this author
Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Publisher:
American Chemical Society Publisher's website
Journal:
Analytical Chemistry Journal website
Volume:
88
Issue:
14
Pages:
7060-7067
Publication date:
2016-06-21
Acceptance date:
2016-06-21
DOI:
EISSN:
1520-6882
ISSN:
0003-2700
Pubs id:
pubs:631003
URN:
uri:e27e2e21-6c02-4800-b080-aa9fdb9c089a
UUID:
uuid:e27e2e21-6c02-4800-b080-aa9fdb9c089a
Local pid:
pubs:631003
Language:
English
Keywords:

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