The understanding and development of rhodium-catalysed asymmetric cross-coupling reactions

Thesis

This thesis examines the understanding and development of Rh(I)-catalysed cross-couplings with arylboronic acids. Our group has previously developed an asymmetric Rh-catalysed Suzuki-Miyaura cross-coupling of racemic allylic halides and boronic acids. Based on a combination of experimental and computational studies, a mechanism is proposed for this highly enantioselective transformation. The first step in the catalytic cycle is irreversible transmetalation. Oxidative addition can happen vi...

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Authors: Van Dijk, L

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: reaction development; catalytic mechanism; asymmetric catalysis
• Subjects: Chemistry, Organic; Reaction mechanisms (Chemistry); Enantioselective catalysis