OS-9: another piece in the HIF complex story.

Journal article

In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005).

Authors: Flashman, E; McDonough, M; Schofield, C

• Publication status: Published
• Journal: Molecular cell
• Volume: 17
• Issue: 4
• Pages: 472-473
• Publication date: 2005-02-01
• DOI: 10.1016/j.molcel.2005.02.001
• EISSN: 1097-4164
• ISSN: 1097-2765
• Language: English
• Keywords: Transcription Factors; Proteasome Endopeptidase Complex; Hydroxylation; Cell Hypoxia; Tumor Suppressor Proteins; Neoplasm Proteins; Ubiquitin-Protein Ligases; Hypoxia-Inducible Factor 1, alpha Subunit; Oxygen; Humans; Lectins; Von Hippel-Lindau Tumor Suppressor Protein; Procollagen-Proline Dioxygenase