Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression.

Journal article

Vascular endothelial growth factor (VEGF) is an important factor mediating tumour angiogenesis. VEGF mRNA is differentially expressed in bladder cancer with high expression in superficial tumours (stage pTa and pT1) contrasting with low expression in muscle invasive tumours (stage > or = pT2). To investigate mechanisms regulating VEGF expression in bladder cancer, VEGF mRNA and protein were measured in normal bladder (n = 12) and primary bladder cancers (n = 57). VEGF protein levels correl...

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Authors: Crew, J; Fuggle, S; Bicknell, R; Cranston, D; de Benedetti, A

• Publication status: Published
• Journal: British journal of cancer
• Volume: 82
• Issue: 1
• Pages: 161-166
• Publication date: 2000-01-01
• DOI: 10.1054/bjoc.1999.0894
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Urinary Bladder; Vascular Endothelial Growth Factor A; RNA, Messenger; Protein Biosynthesis; Endothelial Growth Factors; Neoplasm Proteins; Vascular Endothelial Growth Factors; Humans; Eukaryotic Initiation Factor-4E; Urinary Bladder Neoplasms; Neoplasm Invasiveness; Enzyme-Linked Immunosorbent Assay; Carcinoma, Transitional Cell; Lymphokines; Peptide Initiation Factors