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Impaired TLR5 functionality is associated with survival in melioidosis.

Abstract:

Melioidosis is infection caused by the flagellated saprophyte Burkholderia pseudomallei. TLR5 is a pathogen recognition receptor activated by bacterial flagellin. We studied a genetic variant that encodes a defective TLR5 protein, TLR5(1174C)>T, to elucidate the role of TLR5 in melioidosis. We measured NF-κB activation induced by B. pseudomallei in human embryonic kidney-293 cells transfected with TLR5 and found that B. pseudomallei induced TLR5(1174C)- but not TLR5(1174T)-dependent activa...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.1202974

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
190
Issue:
7
Pages:
3373-3379
Publication date:
2013-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e222360e-ca71-4a0e-a1d6-eb04b5f9a4f7
Source identifiers:
387157
Local pid:
pubs:387157

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